Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 9, 2020
Previous Article Next Article

Electropolymerization of chitosan in the presence of CuNPs on the surface of a copper electrode: an advanced nanocomposite for the determination of mefenamic acid and indomethacin in human plasma samples and prevention of drug poisoning

Author affiliations

Abstract

An innovative method was introduced for the electro-polymerization of chitosan on the surface of a copper electrode. Two electrochemical sensors for the detection and determination of indomethacin and mefenamic acid in human plasma samples were constructed based on copper nanoparticles (CuNPs) and poly-chitosan-modified CuNPs, respectively. The electrochemical behaviors of the CuNP-modified copper electrode (CuE) and poly-chitosan-doped CuNP-modified copper electrode (P(CS)-CuNP-CuE) were investigated using differential pulse voltammetry and cyclic voltammetry techniques. The electrochemical results show that CuNPs and P(CS)-CuNPs lead to increased oxidation peak current by the adsorption of indomethacin. According to the obtained results, we inferred that the linear range and low limit of quantification (LLOQ) were 1 nM to 10 mM and 1 nM, respectively.

Graphical abstract: Electropolymerization of chitosan in the presence of CuNPs on the surface of a copper electrode: an advanced nanocomposite for the determination of mefenamic acid and indomethacin in human plasma samples and prevention of drug poisoning

Back to tab navigation

Supplementary files

Article information


Submitted
31 Dec 2019
Accepted
23 Jan 2020
First published
04 Feb 2020

Anal. Methods, 2020,12, 1212-1217
Article type
Paper

Electropolymerization of chitosan in the presence of CuNPs on the surface of a copper electrode: an advanced nanocomposite for the determination of mefenamic acid and indomethacin in human plasma samples and prevention of drug poisoning

F. Farshchi, M. Hasanzadeh, M. Feyziazar, A. Saadati and S. Hassanpour, Anal. Methods, 2020, 12, 1212
DOI: 10.1039/C9AY02789K

Social activity

Search articles by author

Spotlight

Advertisements