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Issue 25, 2019
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Micellar catalysis of an iron(iii)-MOF: enhanced biosensing characteristics

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Abstract

Recent years have seen an enormous growth of interest in enzyme mimics based on porous materials as a substitute for natural enzymes. This interest has been increased to a considerable extent due to the fact that they have outstanding chemical and structural features. Herein, Zr6O8(H2O)8(FeCl-tcpp)2(PCN-222(Fe)) was synthesized via a solvothermal approach with Zr6 clusters as nodes and Fe–TCPP (TCPP = tetrakis(4-carboxyphenyl)porphyrin) as a heme-like ligand and was characterized by various techniques such as XRD, TEM, SEM, XPS, UV-vis and IR. Also, since the achievement of high enzyme-like activity of some nanoparticles has attracted widespread interest in recent years, for the first time, we have applied a significant approach by modifying PCN-222(Fe) with sodium dodecyl sulfate (SDS) micelles (SDS/PCN-222(Fe)). In an attempt to explore the significance of this procedure, initially, peroxidase and catalase-like activity were investigated through a reaction with a chromogenic substrate 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS). Based on the high peroxidatic activity of SDS/PCN-222(Fe), a visual, sensitive and reliable method was established for detection of H2O2 with a linear range of 3–200 μM and limit of detection (LOD) of 2 μM. Also, as an implication of these findings, the SDS/Zr6O8(H2O)8(FeCl-tcpp)2 (SDS/PCN-222(Fe)) based system could also be used for glucose assay with a LOD of 3 μM indicating potential applications in clinical medicine. In order to prove this hypothesis, the glucose detection in human serum was determined. Finally, on the basis of SDS/PCN-222(Fe) performance, three natural antioxidants, gallic acid (GA), tannic acid (TA), and ascorbic acid (AA) were applied to explore antioxidant capabilities.

Graphical abstract: Micellar catalysis of an iron(iii)-MOF: enhanced biosensing characteristics

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Supplementary files

Article information


Submitted
24 Feb 2019
Accepted
09 May 2019
First published
13 May 2019

Anal. Methods, 2019,11, 3175-3187
Article type
Paper

Micellar catalysis of an iron(III)-MOF: enhanced biosensing characteristics

M. Aghayan, A. Mahmoudi, S. Sohrabi, S. Dehghanpour, K. Nazari and N. Mohammadian-Tabrizi, Anal. Methods, 2019, 11, 3175
DOI: 10.1039/C9AY00399A

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