Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 10, 2019
Previous Article Next Article

Lanthanide coordination polymer-based biosensor for citrate detection in urine

Author affiliations

Abstract

Recently, lanthanide coordination polymers (LCPs) have emerged as promising materials for biosensing due to their tunability. In this study, utilizing terbium ion (Tb3+) as a luminescence center and guanosine-5′-monophosphate (GMP) as an organic ligand, we designed a Tb–GMP LCP-based biosensor for citrate (Cit) detection. Tb–GMP is weakly luminescent in nature; however, interestingly, after the addition of Cit, a 6.5 times fluorescence enhancement was observed owing to the removal of coordinated water molecules by Cit and the intramolecular energy transfer from GMP to Tb3+. In this assay, the fluorescent intensity of Tb–GMP exhibited a good linear response to Cit concentrations in the range of 4–300 μM with a detection limit of 4 μM. Due to its capability of eliminating autofluorescence, we also applied Tb–GMP for time-gated detection of Cit in urine with promising results. We believe that the current strategy would inspire the development of more LCP-based fluorescent assays or medical imaging platforms for various biological applications.

Graphical abstract: Lanthanide coordination polymer-based biosensor for citrate detection in urine

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Dec 2018, accepted on 05 Jan 2019 and first published on 21 Jan 2019


Article type: Paper
DOI: 10.1039/C8AY02694G
Anal. Methods, 2019,11, 1405-1409

  •   Request permissions

    Lanthanide coordination polymer-based biosensor for citrate detection in urine

    H. Shen, B. Liu, D. Liu, X. Zhu, X. Wei, L. Yu, Q. Shen, P. Qu and M. Xu, Anal. Methods, 2019, 11, 1405
    DOI: 10.1039/C8AY02694G

Search articles by author

Spotlight

Advertisements