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Issue 31, 2018
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A mitochondria-targetable fluorescent probe for detection of bisulfite in living cells

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Abstract

A new colorimetric semi-cyanine fluorescent probe (3) based on benzo[g]indolium was designed and prepared. Probe 3 exhibited a clear OFF–ON fluorescence response at 460 nm toward HSO3 (0–8.0 eq.) within a short response time (3 min). In addition, probe 3 had good selectivity and competitiveness, with excellent sensitivity and a low detection limit (4.4 nM). The detection mechanism relied on nucleophilic HSO3 attacking the C[double bond, length as m-dash]C double bond in a 1,4-nucleophilic addition reaction. Importantly, the confocal fluorescence results indicated that probe 3 targeted mitochondria and could detect HSO3 in living cells.

Graphical abstract: A mitochondria-targetable fluorescent probe for detection of bisulfite in living cells

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Publication details

The article was received on 12 Jul 2018, accepted on 19 Jul 2018 and first published on 19 Jul 2018


Article type: Paper
DOI: 10.1039/C8AY01543K
Citation: Anal. Methods, 2018,10, 3872-3877

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    A mitochondria-targetable fluorescent probe for detection of bisulfite in living cells

    X. Guo, W. Zhu, X. Wei, Y. Xu, R. Sun and J. Ge, Anal. Methods, 2018, 10, 3872
    DOI: 10.1039/C8AY01543K

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