A dual-targeting AS1411-folic acid fluorescent nanocomposite for cancer cell and drug delivery

Jun Ai; Lu Ga; Yong Wang

doi:10.1039/C8AY00410B

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A dual-targeting AS1411-folic acid fluorescent nanocomposite for cancer cell and drug delivery

Jun Ai,

*^ab Lu Ga*^c and Yong Wang^a

Author affiliations

* Corresponding authors

^a College of Chemistry and Enviromental Science, Inner Mongolia Normal University, 81 Zhaowudalu, Hohhot 010022, China
E-mail: imacaj01@163.com

^b Inner Mongolian Key Laboratory for Physics and Chemistry of Functional Materials, Inner Mongolia Normal University, 81 Zhaowudalu, Hohhot 010022, China

^c College of Pharmacy, Inner Mongolia Medical University, Jinchuan Kaifaqu, Hohhot 010110, China
E-mail: 13404832082@163.com

Abstract

In this paper, we report a novel approach for AS1411 G-quadruplex and folic acid-templated dual-targeting fluorescent Au nanocomposite with DOX and its application to bioimaging. For the first time, we demonstrate the method of generating AS1411-folic acid DOX-conjugated gold nanocomposite (AF-D-AuNPs) in aqueous solution for increasing targeting ability.

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Article information

DOI: https://doi.org/10.1039/C8AY00410B
Article type: Communication
Submitted: 23 Feb 2018
Accepted: 04 Apr 2018
First published: 05 Apr 2018

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Anal. Methods, 2018,10, 1949-1951

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A dual-targeting AS1411-folic acid fluorescent nanocomposite for cancer cell and drug delivery

J. Ai, L. Ga and Y. Wang, Anal. Methods, 2018, 10, 1949 DOI: 10.1039/C8AY00410B

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Analytical Methods

A dual-targeting AS1411-folic acid fluorescent nanocomposite for cancer cell and drug delivery

Abstract

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A dual-targeting AS1411-folic acid fluorescent nanocomposite for cancer cell and drug delivery

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