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Issue 20, 2015
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4MBA-labeled Ag-nanorod aggregates coated with SiO2: synthesis, SERS activity, and biosensing applications

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Abstract

A new nanostructure, silica-coated Ag nanorods (NRs) aggregate with 4-mercaptobenzoic acid molecules (4MBA-Ag NRs@SiO2), was prepared by a seed-mediated growth method and a modified Stöber method. In the synthetic process, the optimal 4MBA-Ag NRs@SiO2 was obtained by varying conditions such as surfactant concentration and centrifugation cycles. The morphologies and the optical properties of the 4MBA-Ag NRs@SiO2 were investigated in detail by transmission electron microscope, UV-Vis spectrometer and Raman spectrometer. The experimental results show that the 4MBA-Ag NRs@SiO2 prepared with 0.05 M CTAB has the aggregate morphology of single-crystalline Ag NRs, typical localized surface plasmon resonance (LSPR) characteristics and a high enhancement factor of surface-enhanced Raman scattering (SERS). Based on the SERS activity of 4MBA-Ag NRs@SiO2 and Ag NRs, an immune probe and an immune substrate immobilized with anti-prostate specific antigen (anti-PSA) antibody have been fabricated and used to construct a sandwich structure for a PSA immunoassay; the detection limit of PSA reached 0.3 fg ml−1. It is demonstrated that the as-prepared 4MBA-Ag NRs@SiO2 has great potential in biosensing applications.

Graphical abstract: 4MBA-labeled Ag-nanorod aggregates coated with SiO2: synthesis, SERS activity, and biosensing applications

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Supplementary files

Article information


Submitted
20 Jul 2015
Accepted
05 Sep 2015
First published
08 Sep 2015

Anal. Methods, 2015,7, 8832-8838
Article type
Paper
Author version available

4MBA-labeled Ag-nanorod aggregates coated with SiO2: synthesis, SERS activity, and biosensing applications

W. Lai, J. Zhou, Y. Liu, Z. Jia, S. Xie, L. Petti and P. Mormile, Anal. Methods, 2015, 7, 8832
DOI: 10.1039/C5AY01886B

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