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Issue 15, 2015
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Rapid detection of aspergillosis in immunocompromised patients using DIMS and chemometric analysis

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Abstract

Rapid diagnosis of aspergillosis is one of the most important aspects for disease control and treatment. The purpose of this study was to develop a metabolic fingerprint of serum from immunocompromised patients that can enable rapid detection of aspergillosis. Serum samples from immunocompromised patients with and without aspergillosis were analyzed by direct infusion mass spectrometry (DIMS). Data from the mass spectra were subjected to chemometric analysis using principal component analysis and partial least squares-discriminant analysis. Our method was able to efficiently distinguish patients with and without aspergillosis and predict the presence or absence of aspergillosis in unknown samples. Therefore, DIMS along with chemometric analysis seems to be a promising technique for rapid diagnosis of aspergillosis.

Graphical abstract: Rapid detection of aspergillosis in immunocompromised patients using DIMS and chemometric analysis

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Publication details

The article was received on 04 May 2015, accepted on 27 Jun 2015 and first published on 10 Jul 2015


Article type: Paper
DOI: 10.1039/C5AY01146A
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Anal. Methods, 2015,7, 6346-6351

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    Rapid detection of aspergillosis in immunocompromised patients using DIMS and chemometric analysis

    T. M. G. de Francisco, I. F. Zaramella, J. C. Gasparetto, L. B. Cerqueira, M. S. Piantavini, R. Pontarolo and F. R. Campos, Anal. Methods, 2015, 7, 6346
    DOI: 10.1039/C5AY01146A

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