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Issue 13, 2015
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A novel label-free biosensor based on self-assembled aptamer/GO architecture for sensitive detection of biomolecules

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Abstract

We developed a novel label-free biosensor for biomolecule detection based on the thioflavin T (ThT)-induced conformational change of guanine-rich oligonucleotides and self-assembled aptamer/GO nanosheet architecture. In the presence of target biomolecules, the aptamer sequence could specifically bind to the target and release from the surface of GO nanosheets to form a G-quadruplex conformation with ThT as an inducer, resulting in enhancement of fluorescence. The proposed biosensor exhibits a “turn-on” signal, which allows sensitive, selective and rapid detection of biomolecules.

Graphical abstract: A novel label-free biosensor based on self-assembled aptamer/GO architecture for sensitive detection of biomolecules

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Publication details

The article was received on 29 Apr 2015, accepted on 27 May 2015 and first published on 27 May 2015


Article type: Paper
DOI: 10.1039/C5AY01108F
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Anal. Methods, 2015,7, 5606-5610

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    A novel label-free biosensor based on self-assembled aptamer/GO architecture for sensitive detection of biomolecules

    Z. Huang, J. Ge, L. Liu, J. Jiang, G. Shen and R. Yu, Anal. Methods, 2015, 7, 5606
    DOI: 10.1039/C5AY01108F

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