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Issue 18, 2014
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Comprehensive two-dimensional chromatography for analyzing complex samples: recent new advances

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Abstract

Comprehensive two dimensional chromatography (C2DC) including comprehensive two dimensional gas chromatography (GC × GC), comprehensive two dimensional liquid chromatography (LC × LC) and comprehensive two dimensional supercritical fluid chromatography (SFC × SFC) has become an effective tool to separate complex samples. GC × GC is suitable for the separation of volatile and semi-volatile compounds while LC × LC and SFC × SFC for semi- and non-volatile compounds. This review highlights the fundamental advances of C2DC on the interface techniques, orthogonality and data handling in recent years. The C2DC methods were applied in petrochemicals, medicines, foods, metabolomics, environment, etc.

Graphical abstract: Comprehensive two-dimensional chromatography for analyzing complex samples: recent new advances

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Article information


Submitted
03 May 2014
Accepted
18 Jun 2014
First published
18 Jun 2014

Anal. Methods, 2014,6, 7112-7123
Article type
Critical Review
Author version available

Comprehensive two-dimensional chromatography for analyzing complex samples: recent new advances

X. Shi, S. Wang, Q. Yang, X. Lu and G. Xu, Anal. Methods, 2014, 6, 7112
DOI: 10.1039/C4AY01055H

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