Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 13, 2014
Previous Article Next Article

Hydride-based HPLC stationary phases: a rapidly evolving technology for the development of new bio-analytical methods

Author affiliations

Abstract

This review focuses on the application of various silica hydride stationary phases under conditions that enable the advantages of reversed-phase, aqueous normal phase and organic normal phase selectivity to be gained. Here, an overview is given related to the characteristics of the most frequently used silica hydride stationary phases, including those involving short n-alkyl chain (Diamond Hydride), phenyl, octyl, octadecyl and cholesterol phases. Explanations are provided to account for their unique retention properties, which enable their versatile application in the analysis of biological and pharmaceutical samples under conditions significantly different to those employed with conventional silica-based reversed phase or hydrophilic interaction stationary phase materials.

Graphical abstract: Hydride-based HPLC stationary phases: a rapidly evolving technology for the development of new bio-analytical methods

Back to tab navigation

Article information


Submitted
17 Jan 2014
Accepted
29 Apr 2014
First published
09 May 2014

Anal. Methods, 2014,6, 4496-4503
Article type
Minireview
Author version available

Hydride-based HPLC stationary phases: a rapidly evolving technology for the development of new bio-analytical methods

J. J. Pesek, R. I. Boysen, M. T. W. Hearn and M. T. Matyska, Anal. Methods, 2014, 6, 4496
DOI: 10.1039/C4AY00160E

Social activity

Search articles by author

Spotlight

Advertisements