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Issue 5, 2013

Near infrared spectroscopy combination with PLS to monitor the parameters of naproxen tablet preparation process

Author affiliations

Abstract

Near infrared spectroscopy (NIRs) in combination with chemometrical techniques partial least squares is an effective, expeditious and nondestructive technique to analyse various parameters of interest to the pharmaceutical industry. In this work, we explored the use of NIR spectroscopy for the determination of physical (compression force, tablet hardness, mean particle size and particle size distribution) and chemical parameters (content uniformity). To measure tablet content uniformity, naproxen tablets with drug content ranging from 80% to 120% were made and analyzed using high performance liquid chromatography (HPLC) and NIR spectroscopy. For models of the compression force and hardness, the tablets were made by Rotary tablet press and the compression force was varied from 5.7 to 46.0 kN. The samples of mean particle size and particle size distribution were passed through sieves of different sieve opening to obtain six size fractions. The correlation coefficient (R), root mean square error of calibration (RMSEC), root mean square error of prediction (RMSEP) and root mean square error of cross-validation (RMSECV) have been used to assess the predictive ability and robustness of the different partial least squares (PLS) models.

Graphical abstract: Near infrared spectroscopy combination with PLS to monitor the parameters of naproxen tablet preparation process

Article information


Submitted
24 Oct 2012
Accepted
26 Dec 2012
First published
04 Jan 2013

Anal. Methods, 2013,5, 1337-1345
Article type
Paper

Near infrared spectroscopy combination with PLS to monitor the parameters of naproxen tablet preparation process

W. Luo, J. Wu, X. Wang, X. Lin and H. Li, Anal. Methods, 2013, 5, 1337 DOI: 10.1039/C2AY26260F

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