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Issue 1, 2013
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Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: self-reporting scaffolds for application in tissue engineering

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Abstract

Ratiometric analyte responsive nanosensors have been incorporated into electrospun poly(lactic-co-glycolic) acid (PLGA) fibres to create self-reporting scaffolds. It has been demonstrated that the self-reporting scaffolds could be utilised to monitor microenvironment conditions without damaging the fabricated scaffold or the cells being cultured upon the construct. This presents opportunities to fully understand, monitor and optimise the growth of 3D model tissue constructs in vitro.

Graphical abstract: Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: self-reporting scaffolds for application in tissue engineering

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Publication details

The article was received on 18 Jul 2012, accepted on 13 Nov 2012 and first published on 27 Nov 2012


Article type: Communication
DOI: 10.1039/C2AY25771H
Anal. Methods, 2013,5, 68-71

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    Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: self-reporting scaffolds for application in tissue engineering

    H. C. Harrington, F. R. A. J. Rose, Y. Reinwald, L. D. K. Buttery, A. M. Ghaemmaghami and J. W. Aylott, Anal. Methods, 2013, 5, 68
    DOI: 10.1039/C2AY25771H

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