Preparation of porous functional polymer by a simple method and its application in high performance liquid chromatography

Abstract

A uniform porous functional polymer was prepared by reversible addition–fragmentation chain transfer (RAFT) polymerization. In the process, S,S′-bis (α,α′dimethyl acetic acid) trithiocarbonate was used as the RAFT agent, 2,2-azobis (2-methylpropionitrpionitrile) was used as the initiator; vinyl carboxylate and methyl methacrylate were used as co-monomers; dodecyl alcohol and methanol roles were co-porogens. Morphology of the monolith was confirmed by scanning electron microscopy (SEM). Functional groups in the monolith were assayed by infrared (IR) spectrometry and pore size distribution was determined by a mercury porosimeter. The functional polymer was used as an HPLC stationary phase directly to separate immunoglobulin G from human plasma successfully in a short time (7 min).