Issue 9, 2012

Evaluation of glycol chitosan-graft-carboxymethyl β-cyclodextrin as potential pH-sensitive anticancer drug carrier by surface plasmon resonance

Abstract

A novel pH-sensitive anticancer drug carrier glycol chitosan-graft-carboxymethyl β-cyclodextrin (GCH-g-CM β-CD) was successfully synthesized by a simple method, and its interaction processes with porcine gastric mucin (PGM) and doxorubicin (DXR) were recorded by surface plasmon resonance (SPR) in real time. Owing to the mucoadhesive property of GCH, GCH-g-CM β-CD could immobilize on the PGM modified Au film, indicating its targeting delivery behavior. More importantly, due to the free carboxylic acid groups around the cavity of β-CD, the carrier could release DXR in acid medium (pH 5.0), but could not release them in weakly basic medium (pH 7.4). That is to say, the novel carrier not only possesses the targeting delivery behavior of GCH and hydrophobic drug inclusion feature of β-CD, but also can release the drug by controlling pH in physiological range. Therefore, GCH-g-CM β-CD has great potential application as a novel anticancer drug carrier.

Graphical abstract: Evaluation of glycol chitosan-graft-carboxymethyl β-cyclodextrin as potential pH-sensitive anticancer drug carrier by surface plasmon resonance

Supplementary files

Article information

Article type
Paper
Submitted
02 Feb 2012
Accepted
24 May 2012
First published
30 May 2012

Anal. Methods, 2012,4, 2784-2790

Evaluation of glycol chitosan-graft-carboxymethyl β-cyclodextrin as potential pH-sensitive anticancer drug carrier by surface plasmon resonance

H. Tan, Y. Xue, Q. Luan and X. Yao, Anal. Methods, 2012, 4, 2784 DOI: 10.1039/C2AY25295C

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