Issue 6, 2012
From the journal:

Analytical Methods

Multiplex relative quantitation of peptides and proteins using amine-reactive metal element chelated tags coupled with mass spectrometry†

Xin Wang,ab   Yangjun Zhang,*a   Xueying Wang,a   Hongjun Lin,a   Weijie Qina  and  Xiaohong Qian*a  

* Corresponding authors

a State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, National Engineering Research Center for Protein Drugs, No.33 Life Science Park Road, Changping District, Beijing 102206, P. R. China
E-mail: zhangyangjun6314@yahoo.com.cn, qianxh1@163.com
Fax: +86 80705155

b Institute of Chemical Defense, Beijing, P. R. China

Abstract

Here we describe a chemical labeling method for multiplex relative quantitation of peptides and proteins by coupling metal element chelated tags (MECT) to peptides followed by mass spectrometric analysis.

Graphical abstract: Multiplex relative quantitation of peptides and proteins using amine-reactive metal element chelated tags coupled with mass spectrometry

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Article information

DOI
https://doi.org/10.1039/C2AY25275A
Article type
Communication
Submitted
16 Mar 2012
Accepted
26 Apr 2012
First published
30 Apr 2012

Anal. Methods, 2012,4, 1629-1632

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Multiplex relative quantitation of peptides and proteins using amine-reactive metal element chelated tags coupled with mass spectrometry

X. Wang, Y. Zhang, X. Wang, H. Lin, W. Qin and X. Qian, Anal. Methods, 2012, 4, 1629 DOI: 10.1039/C2AY25275A

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