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Issue 8, 2012
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Determination of enantiomer compositions of propranolol enantiomers by chiral ionic liquid as a chiral selector and the UV-assisted spectrophotometric method

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Abstract

Many chiral selectors have been used for recognition of enantiomeric compounds but their synthesis involves time-consuming and expensive multistep-processes with almost not optically pure products. In this paper, 1-butyl-3-methylimidazolium (T-4)-bis[(αS)-α-(hydroxy-O) benzeneacetato-κO] borate, a chiral ionic liquid which can be easily synthesized, was first used as a chiral selector in solution. The enantiomer compositions of propranolol hydrochloride were determined by using this chiral selector and the spectrophotometric method. The data of UV spectra showed that S-propranolol hydrochloride could be recognized in the mixture of the enantiomers with a total concentration of 1.50 × 10−4 M.

Graphical abstract: Determination of enantiomer compositions of propranolol enantiomers by chiral ionic liquid as a chiral selector and the UV-assisted spectrophotometric method

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Article information


Submitted
14 Feb 2012
Accepted
08 Jun 2012
First published
13 Jun 2012

Anal. Methods, 2012,4, 2283-2287
Article type
Paper

Determination of enantiomer compositions of propranolol enantiomers by chiral ionic liquid as a chiral selector and the UV-assisted spectrophotometric method

G. Absalan, Y. Alipour, Z. Rezaei and M. Akhond, Anal. Methods, 2012, 4, 2283
DOI: 10.1039/C2AY25161B

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