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Issue 12, 2010
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Detection of influenza viruses by a waveguide-mode sensor

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Abstract

Methods are demonstrated for antibody-based detection of influenza viruses using the monolithic-sensing-plate technology of an evanescent-field-coupled waveguide-mode sensor. To facilitate the detection of viruses at lower concentrations, a strategy of complexing the virus with Coomassie Brilliant Blue dye was used to amplify the signal. By applying this method, hemagglutinins from avian influenza virus (H5N1) and human influenza virus (A/Panama/2007/1999) were detected. An intact human influenza virus (A/Brisbane/59/2007) was also detected. The method is suitable for the detection of virulent viruses that may emerge at various stages of evolution.

Graphical abstract: Detection of influenza viruses by a waveguide-mode sensor

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Publication details

The article was received on 10 Aug 2010, accepted on 22 Sep 2010 and first published on 26 Oct 2010


Article type: Paper
DOI: 10.1039/C0AY00491J
Anal. Methods, 2010,2, 1880-1884

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    Detection of influenza viruses by a waveguide-mode sensor

    S. C. B. Gopinath, K. Awazu and M. Fujimaki, Anal. Methods, 2010, 2, 1880
    DOI: 10.1039/C0AY00491J

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