Enantioanalysis of S-Ibuprofen using [5–6] fullerene-C70 and diethyl (1,2-methanofullerene C70)-71-71-dicarboxylate

Abstract

[5–6] Fullerene-C₇₀ and diethyl (1,2-methanofullerene C₇₀)-71-71-dicarboxylate are used as chiral selectors for the construction of enantioselective, potentiometric membrane electrodes used in the enantioanalysis of S-Ibuprofen. The sensitivities (slopes) of the electrodes were 55.70 mV/pS-ibuprofen for [5–6] fullerene-C₇₀ based electrode and 56.10 mV/pS-ibuprofen for diethyl (1,2-methanofullerene C₇₀)-71-71-dicarboxylate based electrodes and the linear concentration ranges were between 10⁻¹⁰ and 10⁻³ mol L⁻¹ (limit of detection 1 × 10⁻¹¹ mol L⁻¹), and between 10⁻¹⁰ and 10⁻⁴ mol L⁻¹ (limit of detection 5.4 × 10⁻¹¹ mol L⁻¹), respectively. The recovery tests proved that these electrodes can be reliable used for the enantioanalysis of S-ibuprofen raw material (recovery higher than 99.00%) and from its pharmaceutical formulations (recovery higher than 98.40%).