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Issue 1, 2010
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Enantioanalysis of S-Ibuprofen using [5–6] fullerene-C70 and diethyl (1,2-methanofullerene C70)-71-71-dicarboxylate

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Abstract

[5–6] Fullerene-C70 and diethyl (1,2-methanofullerene C70)-71-71-dicarboxylate are used as chiral selectors for the construction of enantioselective, potentiometric membrane electrodes used in the enantioanalysis of S-Ibuprofen. The sensitivities (slopes) of the electrodes were 55.70 mV/pS-ibuprofen for [5–6] fullerene-C70 based electrode and 56.10 mV/pS-ibuprofen for diethyl (1,2-methanofullerene C70)-71-71-dicarboxylate based electrodes and the linear concentration ranges were between 10−10 and 10−3 mol L−1 (limit of detection 1 × 10−11 mol L−1), and between 10−10 and 10−4 mol L−1 (limit of detection 5.4 × 10−11 mol L−1), respectively. The recovery tests proved that these electrodes can be reliable used for the enantioanalysis of S-ibuprofen raw material (recovery higher than 99.00%) and from its pharmaceutical formulations (recovery higher than 98.40%).

Graphical abstract: Enantioanalysis of S-Ibuprofen using [5–6] fullerene-C70 and diethyl (1,2-methanofullerene C70)-71-71-dicarboxylate

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Publication details

The article was received on 11 Mar 2009, accepted on 28 Oct 2009 and first published on 17 Nov 2009


Article type: Paper
DOI: 10.1039/B9AY00086K
Anal. Methods, 2010,2, 37-40

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    Enantioanalysis of S-Ibuprofen using [5–6] fullerene-C70 and diethyl (1,2-methanofullerene C70)-71-71-dicarboxylate

    R. Stefan-van Staden, Anal. Methods, 2010, 2, 37
    DOI: 10.1039/B9AY00086K

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