Jump to main content
Jump to site search
SCHEDULED MAINTENANCE Close the message box

Maintenance work is planned for Monday 16 August 2021 from 07:00 to 23:59 (BST).

Website performance may be temporarily affected and you may not be able to access some PDFs or images. If this does happen, refreshing your web browser should resolve the issue. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 11, 2020

Imaging lipophilic regions in rodent brain tissue with halogenated BODIPY probes

Author affiliations

Abstract

The effect of halogen substitution in fluorescent BODIPY species was evaluated in the context of staining lipids in situ within brain tissue sections. Herein we demonstrate that the halogenated species maintain their known in vitro affinity when applied to detect lipids in situ in brain tissue sections. Interestingly, the chlorine substituted compound revealed the highest specificify for white matter lipids. Furthermore, the halogen substituted compounds rapidly detected lipid enriched cells, in situ, associated with a case of brain pathology and neuroinflammation.

Graphical abstract: Imaging lipophilic regions in rodent brain tissue with halogenated BODIPY probes

Supplementary files

Article information


Submitted
15 Jan 2020
Accepted
24 Apr 2020
First published
27 Apr 2020

Analyst, 2020,145, 3809-3813
Article type
Communication

Imaging lipophilic regions in rodent brain tissue with halogenated BODIPY probes

D. Hartnell, B. J. Schwehr, K. Gillespie-Jones, D. Alwis, R. Rajan, H. Hou, N. J. Sylvain, M. J. Pushie, M. E. Kelly, M. Massi and M. J. Hackett, Analyst, 2020, 145, 3809 DOI: 10.1039/D0AN00099J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements