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Issue 7, 2020
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Imaging mass spectrometry allows for neuroanatomic-specific detection of gangliosides in the healthy and diseased brain

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Abstract

Gangliosides have a wide variety of biological functions due to their location on the outer leaflet of plasma membranes. They form a critical component of membrane rafts, or ganglioside-enriched microdomains, where they influence the physical properties of the membrane as well as its function. Gangliosides can change their structure to meet their external and internal environmental demands. This ability to change structure makes gangliosides both fascinating and technologically challenging targets to identify and understand. A full understanding on how gangliosides are regulated within the central nervous system (CNS) is critical, as ganglioside dysregulation is observed in the aging brain as well as in several neurodegenerative injuries and diseases such as stroke, Alzheimer's disease, Parkinson's disease, Huntington's disease and several lysosomal storage disorders diseases, including Tay Sach's disease. Mass spectrometry (MS) has become a useful means to better understand ganglioside composition and function. Imaging mass spectrometry (IMS) provides the added benefit of placing analytical information within an anatomical context. This review article will discuss recent advances in MS-based detection methods, with a focus on IMS-based approaches to help understand the spatial-specific role gangliosides in the healthy brain as in CNS injuries and disease.

Graphical abstract: Imaging mass spectrometry allows for neuroanatomic-specific detection of gangliosides in the healthy and diseased brain

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Article information


Submitted
12 Nov 2019
Accepted
05 Feb 2020
First published
07 Feb 2020

Analyst, 2020,145, 2473-2481
Article type
Critical Review

Imaging mass spectrometry allows for neuroanatomic-specific detection of gangliosides in the healthy and diseased brain

W. X. Wang and S. N. Whitehead, Analyst, 2020, 145, 2473
DOI: 10.1039/C9AN02270H

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