Issue 22, 2019

Screening of DNA G-quadruplex stabilizing ligands by nano differential scanning fluorimetry

Abstract

G-quadruplex (G4) nucleic acid structures are involved in a number of different diseases and their drug-induced stabilization is deemed to be a promising therapeutic approach. Herein is reported a proof of principle study on the use of nano differential scanning fluorimetry for a rapid and accurate analysis of G4-stabilizing ligands, exploiting the fluorescence properties of a 2-aminopurine modified G4-forming oligonucleotide.

Graphical abstract: Screening of DNA G-quadruplex stabilizing ligands by nano differential scanning fluorimetry

Supplementary files

Article information

Article type
Communication
Submitted
01 Aug 2019
Accepted
04 Oct 2019
First published
07 Oct 2019

Analyst, 2019,144, 6512-6516

Screening of DNA G-quadruplex stabilizing ligands by nano differential scanning fluorimetry

B. Pagano, N. Iaccarino, A. Di Porzio, A. Randazzo and J. Amato, Analyst, 2019, 144, 6512 DOI: 10.1039/C9AN01463B

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