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Issue 21, 2019
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Zero electrical power pump for portable high-performance liquid chromatography

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Abstract

A major trend in analytical chemistry is the miniaturization of laboratory instrumentation. We report a pump requiring no power to operate based on the controlled expansion of a pre-pressurised gas for use in portable applications of high-performance liquid chromatography. The performance of the gas pump is characterised and integrated into a compact liquid chromatography system capable of isocratic separations integrating an LED-based UV-absorption detector. The system weighed 6.7 kg when the mobile phase reservoir was fully charged with 150 mL solvent and included an on-board computer to control the system and analyse data. We characterise the flow-rate through chromatography columns with a variety of geometries and packing materials for a range of pressures up to 150 bar. The maximum variation in flow rate was measured to be 6.5 nL min−1, limited by the resolution of the flow detector. All tests were made on battery power and results are a mixture of those made in the laboratory and in the field. Additionally, we performed a series of 1 m drop tests on the device and show the system's high tolerance to mechanical shocks during operation in the field.

Graphical abstract: Zero electrical power pump for portable high-performance liquid chromatography

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Publication details

The article was received on 11 Jul 2019, accepted on 24 Aug 2019 and first published on 01 Oct 2019


Article type: Paper
DOI: 10.1039/C9AN01302D
Analyst, 2019,144, 6207-6213
  • Open access: Creative Commons BY license
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    Zero electrical power pump for portable high-performance liquid chromatography

    S. Chatzimichail, D. Casey and A. Salehi-Reyhani, Analyst, 2019, 144, 6207
    DOI: 10.1039/C9AN01302D

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