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Issue 23, 2019
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Mass spectrometric analysis of PTM dynamics using stable isotope labeled metabolic precursors in cell culture

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Abstract

Biological organisms represent highly dynamic systems, which are continually exposed to environmental factors and always strive to restore steady-state homeostasis. Posttranslational modifications are key regulators with which biological systems respond to external stimuli. To understand how homeostasis is restored, it is important to study the kinetics of posttranslational modifications. In this review we discuss proteomic approaches using stable isotope labeled metabolic precursors to study dynamics of posttranslational modifications in cell culture.

Graphical abstract: Mass spectrometric analysis of PTM dynamics using stable isotope labeled metabolic precursors in cell culture

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Article information


Submitted
05 Jul 2019
Accepted
13 Oct 2019
First published
25 Oct 2019

Analyst, 2019,144, 6812-6833
Article type
Critical Review

Mass spectrometric analysis of PTM dynamics using stable isotope labeled metabolic precursors in cell culture

A. van Pijkeren, R. Bischoff and M. Kwiatkowski, Analyst, 2019, 144, 6812
DOI: 10.1039/C9AN01258C

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