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Issue 11, 2019
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Sub-ppm level high energy resolution fluorescence detected X-ray absorption spectroscopy of selenium in articular cartilage

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Abstract

The speciation of highly-diluted elements by X-ray absorption spectroscopy in a diverse range of materials is extremely challenging, especially in biological matrices such as articular cartilage. Here we show that using a high energy resolution fluorescence detected X-ray absorption spectroscopy (HERFD-XAS) technique coupled to an array of crystal analyzers, selenium speciation down to 400 ppb (μg kg−1) within articular cartilage can be demonstrated. This is a major advance in the speciation of highly-diluted elements through X-ray absorption spectroscopy and opens new possibilities to study the metabolic role of selenium and other elements in biological samples.

Graphical abstract: Sub-ppm level high energy resolution fluorescence detected X-ray absorption spectroscopy of selenium in articular cartilage

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Supplementary files

Article information


Submitted
29 Jan 2019
Accepted
22 Mar 2019
First published
28 Mar 2019

Analyst, 2019,144, 3488-3493
Article type
Communication

Sub-ppm level high energy resolution fluorescence detected X-ray absorption spectroscopy of selenium in articular cartilage

C. Bissardon, O. Proux, S. Bureau, E. Suess, L. H. E. Winkel, R. S. Conlan, L. W. Francis, I. M. Khan, L. Charlet, J. L. Hazemann and S. Bohic, Analyst, 2019, 144, 3488
DOI: 10.1039/C9AN00207C

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