Issue 13, 2016
From the journal:

Analyst

A dual-channel detection of mercuric ions using a label free G-quadruplex-based DNAzyme molecule†

Long Ma,*abc   Haiyan Liu,bc   Guanrong Wu,bc   Nana Sun,bc   Lingpei Meng,bc   Yuyin Li,bc   Zhenxing Liubc  and  Aipo Diaobc  

* Corresponding authors

a Biomolecular Sciences Research Complex, EaStCHEM School of Chemistry, University of St Andrews, Fife KY16 9ST, UK
E-mail: lm228@st.andrews.ac.uk

b Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, School of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China
E-mail: malong@tust.edu.cn
Fax: +8622 60602298
Tel: +86 22 60602948

c Tianjin Key Laboratory of Industry Microbiology, School of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China
Tel: +0133 446 7254

Abstract

We have constructed a ‘turn-off’ and label free bio-sensor using a DNAzyme molecule. This facile bio-sensor is capable of selective detection of mercuric ions with a high sensitivity and satisfactory dynamic range. More importantly, it is able to generate both fluorescent and colourimetric signals for detection. This dual-channel bio-sensor is expected to afford high detection confidence and overcome false-positive readout especially when assaying complex biological samples.

Graphical abstract: A dual-channel detection of mercuric ions using a label free G-quadruplex-based DNAzyme molecule

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6AN00795C
Article type
Communication
Submitted
05 Apr 2016
Accepted
04 May 2016
First published
20 May 2016

Analyst, 2016,141, 3997-4000

Permissions

Request permissions

A dual-channel detection of mercuric ions using a label free G-quadruplex-based DNAzyme molecule

L. Ma, H. Liu, G. Wu, N. Sun, L. Meng, Y. Li, Z. Liu and A. Diao, Analyst, 2016, 141, 3997 DOI: 10.1039/C6AN00795C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements