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Issue 14, 2016
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Graphene oxide-based electrochemical label-free detection of glycoproteins down to aM level using a lectin biosensor

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Abstract

A label-free ultrasensitive impedimetric biosensor with lectin immobilised on graphene oxide (GO) for the detection of glycoproteins from 1 aM is shown here. This is the first time a functional lectin biosensor with lectin directly immobilised on a graphene-based interface without any polymer modifier has been described. The study also shows that hydrophilic oxidative debris present on GO has a beneficial effect on the sensitivity of (8.46 ± 0.20)% per decade for the lectin biosensor compared to the sensitivity of (4.52 ± 0.23)% per decade for the lectin biosensor built up from GO with the oxidative debris washed out.

Graphical abstract: Graphene oxide-based electrochemical label-free detection of glycoproteins down to aM level using a lectin biosensor

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Supplementary files

Article information


Submitted
05 Apr 2016
Accepted
28 May 2016
First published
31 May 2016

Analyst, 2016,141, 4278-4282
Article type
Communication

Graphene oxide-based electrochemical label-free detection of glycoproteins down to aM level using a lectin biosensor

L. Klukova, J. Filip, S. Belicky, A. Vikartovska and J. Tkac, Analyst, 2016, 141, 4278
DOI: 10.1039/C6AN00793G

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