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Issue 10, 2016
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Rapid and enzyme-free nucleic acid detection based on exponential hairpin assembly in complex biological fluids

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Abstract

Herein, we have developed a rapid and enzyme-free nucleic acid amplification detection method that combined the exponential self-assembly of four DNA hairpins and the FRET pair Cy3 and Cy5. This strategy was very ingenious and rapid, and could detect nucleic acids at concentrations as low as 10 pM in 15 min in biological fluids.

Graphical abstract: Rapid and enzyme-free nucleic acid detection based on exponential hairpin assembly in complex biological fluids

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Publication details

The article was received on 26 Feb 2016, accepted on 19 Apr 2016 and first published on 20 Apr 2016


Article type: Communication
DOI: 10.1039/C6AN00474A
Citation: Analyst, 2016,141, 2883-2886
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    Rapid and enzyme-free nucleic acid detection based on exponential hairpin assembly in complex biological fluids

    C. Ma, M. Zhang, S. Chen, C. Liang and C. Shi, Analyst, 2016, 141, 2883
    DOI: 10.1039/C6AN00474A

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