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Issue 12, 2016
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Quantitative online sheath-flow surface enhanced Raman spectroscopy detection for liquid chromatography

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Abstract

Sheath-flow surface-enhanced Raman spectroscopy (SERS) was used for online detection and quantification of small molecules separated by liquid chromatography. A mixture of model metabolites (thiamine, folic acid, and riboflavin) was separated and characterized by UV-Vis and SERS detectors connected in series. Acetonitrile in the mobile phase provided an internal standard enabling quantitative detection across SERS experiments.

Graphical abstract: Quantitative online sheath-flow surface enhanced Raman spectroscopy detection for liquid chromatography

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Supplementary files

Article information


Submitted
22 Jan 2016
Accepted
05 Apr 2016
First published
05 Apr 2016

Analyst, 2016,141, 3630-3635
Article type
Communication
Author version available

Quantitative online sheath-flow surface enhanced Raman spectroscopy detection for liquid chromatography

A. Nguyen and Z. D. Schultz, Analyst, 2016, 141, 3630
DOI: 10.1039/C6AN00155F

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