Issue 11, 2016
From the journal:

Analyst

A triphenylcyclopropenylium mass tag: synthesis and application to ultrasensitive LC/MS analysis of amines†‡

Artyom P. Topolyan,a   Dina A. Strizhevskaya,a   Maria A. Belyaeva,a   Vladimir A. Brylev,a   Alexey V. Ustinov,*ab   Andrey A. Formanovskya  and  Vladimir A. Korshun*ac  

* Corresponding authors

a Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia
E-mail: korshun@ibch.ru

b Lumiprobe Corp., 1835 E. Hallandale Beach Blvd. #221, Hallandale Beach, FL 33009, USA
E-mail: alex.ustinov@lumiprobe.com

c Gause Institute of New Antibiotics, Bolshaya Pirogovskaya 11, 119021 Moscow, Russia

Abstract

Thiol adducts of triphenylcyclopropenylium undergo efficient heterolytic dissociation under conditions of both electrospray (ESI) and laser desorption ionization (LDI) mass spectrometry giving rise to a prominent signal of an aromatic C3Ph3+ cation. A functionalized mass tagging reagent, an activated ester carrying an S-linked C3Ph3 unit, has been developed and used for the derivatization of amines and their subsequent HPLC/ESI-MS detection in low attomolar amounts.

Graphical abstract: A triphenylcyclopropenylium mass tag: synthesis and application to ultrasensitive LC/MS analysis of amines

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Article information

DOI
https://doi.org/10.1039/C5AN02642C
Article type
Paper
Submitted
25 Dec 2015
Accepted
07 Apr 2016
First published
07 Apr 2016

Analyst, 2016,141, 3289-3295

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A triphenylcyclopropenylium mass tag: synthesis and application to ultrasensitive LC/MS analysis of amines

A. P. Topolyan, D. A. Strizhevskaya, M. A. Belyaeva, V. A. Brylev, A. V. Ustinov, A. A. Formanovsky and V. A. Korshun, Analyst, 2016, 141, 3289 DOI: 10.1039/C5AN02642C

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