Issue 24, 2015
From the journal:

Analyst

High-resolution NMR-based metabolic detection of microgram biopsies using a 1 mm HRμMAS probe†

Yusuke Nishiyama,ab   Yuki Endo,a   Takahiro Nemoto,a   Anne-Karine Bouzier-Sorec  and  Alan Wong*d  

* Corresponding authors

a JEOL RESONANCE Inc., 3-1-2 Musashino, Akishima, Tokyo 196-8558, Japan

b RIKEN CLST-JEOL Collaboration Center, Tsurumi, Yokohama, Kanagawa 230-0045, Japan

c Centre de Résonance Magnétique des Systèmes Biologiques, CNRS-Université de Bordeaux, UMR5536, Bordeaux, France

d CEA Saclay, DSM, IRAMIS, CEA/CNRS UMR3685–NIMBE, Laboratoire Structure et Dynamiquepar Reśonance Magnet́ique, Gif-sur-Yvette Cedex, France
E-mail: alan.wong@cea.fr

Abstract

A prototype 1 mm High-Resolution micro-Magic Angle Spinning (HRμMAS) probe is described. High quality 1H NMR spectra were obtained from 490 μg of heterogeneous biospecimens, offering a rich-metabolite profiling. The results demonstrate the potential of HRμMAS as a new NMR analytical tool in metabolomics.

Graphical abstract: High-resolution NMR-based metabolic detection of microgram biopsies using a 1 mm HRμMAS probe

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Article information

DOI
https://doi.org/10.1039/C5AN01810B
Article type
Communication
Submitted
02 Sep 2015
Accepted
23 Oct 2015
First published
13 Nov 2015

Analyst, 2015,140, 8097-8100

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High-resolution NMR-based metabolic detection of microgram biopsies using a 1 mm HRμMAS probe

Y. Nishiyama, Y. Endo, T. Nemoto, A. Bouzier-Sore and A. Wong, Analyst, 2015, 140, 8097 DOI: 10.1039/C5AN01810B

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