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Issue 19, 2015
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Determination of hematocrit by voltage-induced hemolysis on a disposable electrochemical sensing strip

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Abstract

Besides being a crucial parameter for surgery and clinical diagnosis, hematocrit tends to affect the analytical results of point-of-care analytical devices. Therefore, an accurate and quick method for measuring hematocrit was developed on the basis of screen-printed carbon electrodes (SPCE). An impulse DC voltage of 3.0 V was imposed on ferricyanide-coated SPCE to induce hemolysis, and the released hemoglobin reduced the ferricyanide, generating a higher oxidation current for estimating hematocrit. Hematocrit ranging from 10 to 70% can be determined in 5 s by linear sweep voltammetry (r2 = 0.9907) or 0.8 s by 3 V of potential step voltammetry (r2 = 0.9833).

Graphical abstract: Determination of hematocrit by voltage-induced hemolysis on a disposable electrochemical sensing strip

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Article information


Submitted
23 Jun 2015
Accepted
23 Aug 2015
First published
24 Aug 2015

Analyst, 2015,140, 6619-6624
Article type
Paper

Determination of hematocrit by voltage-induced hemolysis on a disposable electrochemical sensing strip

C. Weng, B. Hsieh, Y. Hou and T. Cheng, Analyst, 2015, 140, 6619
DOI: 10.1039/C5AN01251A

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