Jump to main content
Jump to site search

Issue 12, 2015
Previous Article Next Article

Detection limits of organic compounds achievable with intense, short-pulse lasers

Author affiliations

Abstract

Many organic molecules have strong absorption bands which can be accessed by ultraviolet short pulse lasers to produce efficient ionization. This resonant multiphoton ionization scheme has already been exploited as an ionization source in time-of-flight mass spectrometers used for environmental trace analysis. In the present work we quantify the ultimate potential of this technique by measuring absolute ion yields produced from the interaction of 267 nm femtosecond laser pulses with the organic molecules indole and toluene, and gases Xe, N2 and O2. Using multiphoton ionization cross sections extracted from these results, we show that the laser pulse parameters required for real-time detection of aromatic molecules at concentrations of one part per trillion in air and a limit of detection of a few attomoles are achievable with presently available commercial laser systems. The potential applications for the analysis of human breath, blood and tissue samples are discussed.

Graphical abstract: Detection limits of organic compounds achievable with intense, short-pulse lasers

Back to tab navigation

Supplementary files

Article information


Submitted
17 Mar 2015
Accepted
15 Apr 2015
First published
16 Apr 2015

Analyst, 2015,140, 4270-4276
Article type
Paper
Author version available

Detection limits of organic compounds achievable with intense, short-pulse lasers

J. Miles, S. De Camillis, G. Alexander, K. Hamilton, T. J. Kelly, J. T. Costello, M. Zepf, I. D. Williams and J. B. Greenwood, Analyst, 2015, 140, 4270 DOI: 10.1039/C5AN00529A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements