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Issue 5, 2015
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Preparation of molecularly imprinted polymers for the recognition of proteins via the generation of peptide-fragment binding sites by semi-covalent imprinting and enzymatic digestion

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Abstract

Molecularly imprinted polymers bearing peptide fragment-based binding sites within the protein-imprinted cavities were prepared by copolymerization of the acrylated protein with 6-monoacryloyl-trehalose and 6,6′-diacryloyl-trehalose as a hydrophilic comonomer and a crosslinker respectively, followed by enzymatic decomposition of the grafted protein into the polymer matrix with pepsin, resulting in the creation of peptide fragment-based protein-binding sites.

Graphical abstract: Preparation of molecularly imprinted polymers for the recognition of proteins via the generation of peptide-fragment binding sites by semi-covalent imprinting and enzymatic digestion

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Article information


Submitted
15 Dec 2014
Accepted
16 Jan 2015
First published
28 Jan 2015

Analyst, 2015,140, 1448-1452
Article type
Communication
Author version available

Preparation of molecularly imprinted polymers for the recognition of proteins via the generation of peptide-fragment binding sites by semi-covalent imprinting and enzymatic digestion

H. Taguchi, H. Sunayama, E. Takano, Y. Kitayama and T. Takeuchi, Analyst, 2015, 140, 1448
DOI: 10.1039/C4AN02299H

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