Issue 22, 2014
From the journal:

Analyst

Rituximab–Au nanoprobes for simultaneous dark-field imaging and DAB staining of CD20 over-expressed on Raji cells†

Lin Fan,‡a   Doudou Lou,‡a   Yu Zhang*a  and  Ning Gu*b  

* Corresponding authors

a State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, P. R. China
E-mail: zhangyu@seu.edu.cn
Fax: +86 25 8327 2496
Tel: +86 25 8327 2496

b State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, P. R. China
E-mail: guning@seu.edu.cn
Fax: +86 25 8327 2496
Tel: +86 25 8327 2496

Abstract

A novel dual-modal cell immunodetection method based on both dark-field imaging and catalysis functions of gold nanoparticles has been established, where the Rituximab–Au conjugates were used as nanoprobes to label and image specifically the CD20 overexpressed on the surface of malignant lymphoma cells of Raji with high affinity.

Graphical abstract: Rituximab–Au nanoprobes for simultaneous dark-field imaging and DAB staining of CD20 over-expressed on Raji cells

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Article information

DOI
https://doi.org/10.1039/C4AN01342E
Article type
Communication
Submitted
23 Jul 2014
Accepted
11 Sep 2014
First published
11 Sep 2014

Analyst, 2014,139, 5660-5663

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Rituximab–Au nanoprobes for simultaneous dark-field imaging and DAB staining of CD20 over-expressed on Raji cells

L. Fan, D. Lou, Y. Zhang and N. Gu, Analyst, 2014, 139, 5660 DOI: 10.1039/C4AN01342E

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