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Issue 22, 2014
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Polymer sieving matrices in microanalytical electrophoresis

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Abstract

Microfluidic design has advanced existing protein separation capabilities and supported novel assays. Key metrics for successful protein separations include fast, robust, and sensitive analysis of complex mixtures of bio-macromolecules. Attaining high separation resolution is a chief concern. Here we review recent advances in polymer-based electrophoresis sieving materials that are impacting microfluidic bioanalytical applications. Looking forward, we comment on unmet needs for advanced separation media in micro-to-nanoscale devices.

Graphical abstract: Polymer sieving matrices in microanalytical electrophoresis

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Publication details

The article was received on 01 Jul 2014, accepted on 07 Aug 2014 and first published on 08 Aug 2014


Article type: Critical Review
DOI: 10.1039/C4AN01179A
Citation: Analyst, 2014,139, 5635-5654
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    Polymer sieving matrices in microanalytical electrophoresis

    M. Chung, D. Kim and A. E. Herr, Analyst, 2014, 139, 5635
    DOI: 10.1039/C4AN01179A

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