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Issue 19, 2014
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A napthelene–pyrazol conjugate: Al(iii) ion-selective blue shifting chemosensor applicable as biomarker in aqueous solution

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Abstract

A newly synthesized and crystalographically characterized napthelene–pyrazol conjugate, 1-[(5-phenyl-1H-pyrazole-3-ylimino)-methyl]-naphthalen-2-ol (HL) behaves as an Al(III) ion-selective chemosensor through internal charge transfer (ICT)-chelation-enhanced fluorescence (CHEF) processes in 100 mM HEPES buffer (water–DMSO 5 : 1, v/v) at biological pH with almost no interference of other competitive ions. This mechanism is readily studied from electronic, fluorimetric and 1H NMR titration. The probe (HL) behaved as a highly selective fluorescent sensor for Al(III) ions as low as 31.78 nM within a very short response time (15–20 s). The sensor (HL), which has no cytotoxicity, is also efficient in detecting the distribution of Al(III) ions in HeLa cells via image development under fluorescence microscope.

Graphical abstract: A napthelene–pyrazol conjugate: Al(iii) ion-selective blue shifting chemosensor applicable as biomarker in aqueous solution

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Supplementary files

Article information


Submitted
07 Jun 2014
Accepted
07 Jul 2014
First published
08 Jul 2014

Analyst, 2014,139, 4828-4835
Article type
Paper
Author version available

A napthelene–pyrazol conjugate: Al(III) ion-selective blue shifting chemosensor applicable as biomarker in aqueous solution

M. Mukherjee, S. Pal, S. Lohar, B. Sen, S. Sen, S. Banerjee, S. Banerjee and P. Chattopadhyay, Analyst, 2014, 139, 4828
DOI: 10.1039/C4AN01039F

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