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Issue 20, 2014
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Multiplex single particle analysis in microfluidics

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A straightforward way to measure separated micrometric sized particles in microfluidic flow is reported. The light scattering profile (LSP) of each single particle is fully characterized by using a CMOS-camera based small angle light scattering (SALS) apparatus, ranging from 2° up to 30°. To ensure controlled particle passage through the incident laser, a viscoelastic 3D alignment effect by viscoelastic induced particle migration has been implemented in a simple and cost-effective microfluidic device. Different polystyrene particle sizes are measured in microfluidic flows and the obtained scattering signatures are matched with the Lorenz–Mie based scattering theory. The results confirm the possibility of using this apparatus for real multiplex particle analyses in microfluidic particle flows.

Graphical abstract: Multiplex single particle analysis in microfluidics

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Publication details

The article was received on 06 Jun 2014, accepted on 28 Jul 2014 and first published on 29 Jul 2014

Article type: Paper
DOI: 10.1039/C4AN01033G
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Analyst, 2014,139, 5239-5246

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    Multiplex single particle analysis in microfluidics

    D. Dannhauser, G. Romeo, F. Causa, I. De Santo and P. A. Netti, Analyst, 2014, 139, 5239
    DOI: 10.1039/C4AN01033G

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