Jump to main content
Jump to site search

Issue 20, 2014
Previous Article Next Article

Multiplex single particle analysis in microfluidics

Author affiliations

Abstract

A straightforward way to measure separated micrometric sized particles in microfluidic flow is reported. The light scattering profile (LSP) of each single particle is fully characterized by using a CMOS-camera based small angle light scattering (SALS) apparatus, ranging from 2° up to 30°. To ensure controlled particle passage through the incident laser, a viscoelastic 3D alignment effect by viscoelastic induced particle migration has been implemented in a simple and cost-effective microfluidic device. Different polystyrene particle sizes are measured in microfluidic flows and the obtained scattering signatures are matched with the Lorenz–Mie based scattering theory. The results confirm the possibility of using this apparatus for real multiplex particle analyses in microfluidic particle flows.

Graphical abstract: Multiplex single particle analysis in microfluidics

Back to tab navigation

Publication details

The article was received on 06 Jun 2014, accepted on 28 Jul 2014 and first published on 29 Jul 2014


Article type: Paper
DOI: 10.1039/C4AN01033G
Author version
available:
Download author version (PDF)
Analyst, 2014,139, 5239-5246

  •   Request permissions

    Multiplex single particle analysis in microfluidics

    D. Dannhauser, G. Romeo, F. Causa, I. De Santo and P. A. Netti, Analyst, 2014, 139, 5239
    DOI: 10.1039/C4AN01033G

Search articles by author

Spotlight

Advertisements