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Issue 18, 2014
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Cell electrospinning cardiac patches for tissue engineering the heart

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Abstract

Cell electrospinning has tremendous applicability to a wide range of uses within both the laboratory and clinic. This has directly resulted from the technology's unique ability to immobilize multiple cell types with a wide range of molecules simultaneously within a fiber during the scaffold generation process. The technology has been shown to generate many cell laden complex architectures from true three-dimensional sheets to those multi-core vessels. Although those studies have demonstrated the versatility of this platform biotechnology, we show here for the first time the ability to immobilize primary cardiac myocytes within these fibers in our quest to develop this technology for creating three-dimensional cardiac patches which could be used for repairing, replacing and rejuvenating damaged, diseased and/or ageing cardiac tissues. These advances are unrivalled by any other technology currently available in the regenerative medicine toolbox, and have many interesting ramifications for repairing a damaged heart.

Graphical abstract: Cell electrospinning cardiac patches for tissue engineering the heart

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Publication details

The article was received on 01 May 2014, accepted on 02 Jul 2014 and first published on 03 Jul 2014


Article type: Communication
DOI: 10.1039/C4AN00766B
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Citation: Analyst, 2014,139, 4449-4452
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    Cell electrospinning cardiac patches for tissue engineering the heart

    E. Ehler and S. N. Jayasinghe, Analyst, 2014, 139, 4449
    DOI: 10.1039/C4AN00766B

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