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Issue 14, 2014
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Microarray-based resonance light scattering assay for detecting DNA methylation and human DNA methyltransferase simultaneously with high sensitivity

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Abstract

A microarray-based resonance light scattering assay, with the combination of methylation-sensitive endonuclease and gold nanoparticle (GNP) probes, has been proposed to sensitively distinguish the DNA methylation level as low as 0.01% (10 pM methylated DNA in 100 nM total DNA) and detect human DNA methyltransferase 1 (Dnmt1) down to 0.1 U mL−1.

Graphical abstract: Microarray-based resonance light scattering assay for detecting DNA methylation and human DNA methyltransferase simultaneously with high sensitivity

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Article information


Submitted
17 Feb 2014
Accepted
01 May 2014
First published
01 May 2014

Analyst, 2014,139, 3537-3540
Article type
Communication
Author version available

Microarray-based resonance light scattering assay for detecting DNA methylation and human DNA methyltransferase simultaneously with high sensitivity

L. Ma, M. Su, T. Li and Z. Wang, Analyst, 2014, 139, 3537
DOI: 10.1039/C4AN00336E

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