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Issue 6, 2014
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Porous layer open tubular columns in capillary liquid chromatography

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Abstract

This review covers the latest developments and applications of porous layer open tubular columns in capillary liquid chromatography. Here, the authors provide a concise background on the fundamentals of porous layer open tubular columns, their fabrication and application. Over the past two decades, growing interest in the areas of proteomics and hyphenated LC-MS techniques have played a large part in the development of porous layer structures within capillary formats due to their high permeability, excellent efficiency and exceptional peak capacity. This review gives a brief overview of open tubular columns in general, however, it focuses predominantly on the applications of covalently bonded porous layer open tubular columns in liquid chromatography. Open tubular columns containing non-bonded or electrostatically attached layers will not be discussed in detail.

Graphical abstract: Porous layer open tubular columns in capillary liquid chromatography

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Article information


Submitted
03 Oct 2013
Accepted
12 Dec 2013
First published
16 Dec 2013

Analyst, 2014,139, 1292-1302
Article type
Critical Review

Porous layer open tubular columns in capillary liquid chromatography

D. A. Collins, E. P. Nesterenko and B. Paull, Analyst, 2014, 139, 1292
DOI: 10.1039/C3AN01869E

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