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Issue 1, 2014
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Amplified plasmonic detection of DNA hybridization using doxorubicin-capped gold particles

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Abstract

We show in this article that doxorubicin-modified gold nanoparticles (Au NP-DOX) can be used for the post-amplification of the wavelength shift of localized surface plasmon resonance (LSPR) signals after DNA hybridization events. We take advantage of the intercalation properties of DOX with guanine-rich oligonucleotides and the plasmon coupling between surface-linked gold nanostructures and Au NP-DOX in solution to detect in a sensitive manner DNA hybridisation events. Post-treatment of double-stranded DNA with Au NP-DOX resulted in a detection limit of ≈600 pM, several times lower than that without post-incubation (LOD ≈ 40 nM).

Graphical abstract: Amplified plasmonic detection of DNA hybridization using doxorubicin-capped gold particles

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Article information


Submitted
19 Sep 2013
Accepted
24 Oct 2013
First published
25 Oct 2013

Analyst, 2014,139, 157-164
Article type
Paper

Amplified plasmonic detection of DNA hybridization using doxorubicin-capped gold particles

J. Spadavecchia, R. Perumal, A. Barras, J. Lyskawa, P. Woisel, W. Laure, C. Pradier, R. Boukherroub and S. Szunerits, Analyst, 2014, 139, 157
DOI: 10.1039/C3AN01794J

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