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Issue 23, 2013
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Measuring and modelling cell-to-cell variation in uptake of gold nanoparticles

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Abstract

The cell-to-cell variation of gold nanoparticle (GNP) uptake is important for therapeutic applications. We directly counted the GNPs in hundreds of individual cells, and showed that the large variation from cell-to-cell could be directly modelled by assuming log-normal distributions of both cell mass and GNP rate of uptake. This was true for GNPs non-specifically bound to fetal bovine serum or conjugated to a cell penetrating peptide. Within a population of cells, GNP content varied naturally by a factor greater than 10 between individual cells.

Graphical abstract: Measuring and modelling cell-to-cell variation in uptake of gold nanoparticles

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Supplementary files

Article information


Submitted
23 Jul 2013
Accepted
26 Sep 2013
First published
26 Sep 2013

This article is Open Access

Analyst, 2013,138, 7070-7074
Article type
Communication

Measuring and modelling cell-to-cell variation in uptake of gold nanoparticles

J. Charles. G. Jeynes, C. Jeynes, M. J. Merchant and K. J. Kirkby, Analyst, 2013, 138, 7070
DOI: 10.1039/C3AN01406A

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