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Issue 19, 2013
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Functionalized viral nanoparticles as ultrasensitive reporters in lateral-flow assays

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Abstract

Two types of viral nanoparticles were functionalized with target-specific antibodies and multiple copies of an enzymatic reporter (horseradish peroxidase). The particles were successfully integrated into an immunochromatographic assay detecting MS2 bacteriophage, a model for viral pathogens. The sensitivity of the assay was greatly superior to conventional gold nanoparticle lateral flow assays, and results could easily be evaluated, even without advanced lab instruments.

Graphical abstract: Functionalized viral nanoparticles as ultrasensitive reporters in lateral-flow assays

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Publication details

The article was received on 01 May 2013, accepted on 23 Jul 2013 and first published on 25 Jul 2013


Article type: Communication
DOI: 10.1039/C3AN00891F
Citation: Analyst, 2013,138, 5584-5587
  • Open access: Creative Commons BY license
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    Functionalized viral nanoparticles as ultrasensitive reporters in lateral-flow assays

    M. Adhikari, S. Dhamane, A. E. V. Hagström, G. Garvey, W. Chen, K. Kourentzi, U. Strych and R. C. Willson, Analyst, 2013, 138, 5584
    DOI: 10.1039/C3AN00891F

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