Issue 5, 2013

A novel platform for enhanced biosensing based on the synergy effects of electrospun polymer nanofibers and graphene oxides

Abstract

A novel biosensing platform was developed by combining the advantages of electrospun poly(vinyl alcohol) (PVA)/chitosan nanofibers and graphene oxides (GO). Glucose oxidase (GOD) was employed as a model enzyme. By co-electrospinning the solution of PVA, chitosan, GOD and GO, the PVA/chitosan/GOD/GO nanofibers were directly modified on the platinum (Pt) electrode. The UV-vis spectra and the FTIR spectra were used to characterize the GO nanosheets. The morphologies of fabricated electrospun nanofibers were characterized by high resolution scanning electron microscopy. After a thin layer of nafion was modified on the surface of matrix, the as-prepared electrode was used to detect glucose. The electrode exhibited great advantages in high sensitivity, low detection limit and wide linear range. In the meantime, the electrode showed good stability, acceptable reproducibility, and excellent anti-interference capability for ascorbic acid, uric acid, lactose and sucrose. Moreover, the novel biosensor was successfully applied for the glucose determination in human serum samples. The mechanism of efficient biosensing of the nafion/PVA/chitosan/GOD/GO/Pt electrode was analyzed in detail and the results show that it can be due to the synergy effects of electrospun nanofibers and GO nanosheets.

Graphical abstract: A novel platform for enhanced biosensing based on the synergy effects of electrospun polymer nanofibers and graphene oxides

Supplementary files

Article information

Article type
Paper
Submitted
11 Nov 2012
Accepted
17 Dec 2012
First published
18 Dec 2012

Analyst, 2013,138, 1459-1466

A novel platform for enhanced biosensing based on the synergy effects of electrospun polymer nanofibers and graphene oxides

X. Su, J. Ren, X. Meng, X. Ren and F. Tang, Analyst, 2013, 138, 1459 DOI: 10.1039/C2AN36663K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements