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Issue 5, 2013
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Adsorptive stripping voltammetric determination of imipramine, trimipramine and desipramine employing titanium dioxide nanoparticles and an Amberlite XAD-2 modified glassy carbon paste electrode

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Abstract

An Amberlite XAD-2 (XAD2) and titanium dioxide nanoparticles (TNPs) modified glassy carbon paste electrode (XAD2-TNP-GCPE) was developed for the determination of imipramine (IMI), trimipramine (TRI) and desipramine (DES). The electrochemical behavior of these molecules was investigated employing cyclic voltammetry (CV), chronocoulometry (CC), electrochemical impedance spectroscopy (EIS) and adsorptive stripping differential pulse voltammetry (AdSDPV). After optimization of analytical conditions using a XAD2-TNP-GCPE electrode at pH 6.0 phosphate buffer (0.1 M), the peak currents were found to vary linearly with its concentration in the range of 1.30 × 10−9 to 6.23 × 10−6 M for IMI, 1.16 × 10−9 to 6.87 × 10−6 M for TRI and 1.43 × 10−9 to 5.68 × 10−6 M for DES. The detection limits (S/N = 3) of 3.93 × 10−10, 3.51 × 10−10 and 4.35 × 10−10 M were obtained for IMI, TRI and DES respectively using AdSDPV. The prepared modified electrode showed several advantages such as a simple preparation method, high sensitivity, very low detection limits and excellent reproducibility. The proposed method was employed for the determination of IMI, TRI and DES in pharmaceutical formulations, blood serum and urine samples.

Graphical abstract: Adsorptive stripping voltammetric determination of imipramine, trimipramine and desipramine employing titanium dioxide nanoparticles and an Amberlite XAD-2 modified glassy carbon paste electrode

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Supplementary files

Article information


Submitted
16 Sep 2012
Accepted
03 Jan 2013
First published
07 Jan 2013

Analyst, 2013,138, 1395-1404
Article type
Paper

Adsorptive stripping voltammetric determination of imipramine, trimipramine and desipramine employing titanium dioxide nanoparticles and an Amberlite XAD-2 modified glassy carbon paste electrode

B. J. Sanghavi and A. K. Srivastava, Analyst, 2013, 138, 1395
DOI: 10.1039/C2AN36330E

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