Issue 21, 2012
From the journal:

Analyst

Rapid and direct detection of attomole adenosine triphosphate (ATP) by MALDI-MS using rutile titania chips†

Muthu Manikandan,ac   Nazim Hasana  and  Hui-Fen Wu*abcd  

* Corresponding authors

a Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan
E-mail: hwu@faculty.nsysu.edu.tw
Fax: +886-7-5253908
Tel: +886-7-5252000-3955

b School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan

c Center for Nanoscience and Nanotechnology, National Sun Yat-Sen University, Kaohsiung, Taiwan

d Doctoral Degree Program in Marine Biotechnology, National Sun Yat-Sen University, Kaohsiung, Taiwan

Abstract

We report the rutile titania-based capture of ATP and its application as a MALDI-MS target plate. This chip, when immersed in solutions containing different concentrations of ATP, can capture ATP and lead to its successful detection in MALDI-MS. We have optimized the ideal surface, showing an increased capture efficacy of the 900 °C (rutile) titania surfaces. We demonstrate the use of this chip as a target plate for direct analysis of the attached ATP using MALDI-MS, down to attomolar concentrations. This chip has a promising future for the detection of ATP in environmental samples, which may eventually be used as a pollution indicator in particular environments.

Graphical abstract: Rapid and direct detection of attomole adenosine triphosphate (ATP) by MALDI-MS using rutile titania chips

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Article information

DOI
https://doi.org/10.1039/C2AN35754B
Article type
Paper
Submitted
12 Apr 2012
Accepted
28 Aug 2012
First published
29 Aug 2012

Analyst, 2012,137, 5128-5134

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Rapid and direct detection of attomole adenosine triphosphate (ATP) by MALDI-MS using rutile titania chips

M. Manikandan, N. Hasan and H. Wu, Analyst, 2012, 137, 5128 DOI: 10.1039/C2AN35754B

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