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Issue 12, 2012
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Ultrasensitive detection of potassium ions based on target induced DNA conformational switch enhanced fluorescence polarization

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Abstract

We have developed a simple, highly sensitive and selective fluorescence polarization assay for the detection of potassium ions based on target induced DNA conformational switch from hairpin to G-quadruplex enhanced fluorescence polarization. The assay was applied in the detection of low nM concentrations of potassium ions and was highly selective over other cations.

Graphical abstract: Ultrasensitive detection of potassium ions based on target induced DNA conformational switch enhanced fluorescence polarization

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Article information


Submitted
19 Feb 2012
Accepted
23 Apr 2012
First published
24 Apr 2012

Analyst, 2012,137, 2770-2773
Article type
Communication

Ultrasensitive detection of potassium ions based on target induced DNA conformational switch enhanced fluorescence polarization

K. Hu, Y. Huang, S. Zhao, J. Tian, Q. Wu, G. Zhang and J. Jiang, Analyst, 2012, 137, 2770
DOI: 10.1039/C2AN35416K

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