Issue 11, 2012
From the journal:

Analyst

Nanostructured silicon surface modifications for as a selective matrix-free laser desorption/ionization mass spectrometry

C. W. Tsao,a   C. H. Lin,b   Y. C. Cheng,cd   C. C. Chien,def   C. C. Changg  and  W. Y. Chen*b  

* Corresponding authors

a Department of Mechanical Engineering, National Central University, Jhongli, Taiwan

b Department of Chemical & Materials Engineering, National Central University, Jhongli, Taiwan
E-mail: wychen@ncu.edu.tw
Fax: +886-3-4225258
Tel: +886-3-4227151 extn 34222

c Department of Medical Research, Cathay General Hospital, Taipei, Taiwan

d Institute of Biomedical Engineering, National Central University, Jhongli, Taiwan

e Department of Anesthesiology, Sijhih Cathay General Hospital, Sijhih City, Taipei, Taiwan

f College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan

g Division of Rheumatology, Immunology and Allergy, Taipei Medical University Hospital, Taipei, Taiwan

Abstract

Matrix-assisted laser desorption/ionization mass spectrometry is an established soft ionization method that is widely applied to analyze biomolecules. The UV-absorbing organic matrix is essential for biomolecule ionization; however, it also creates matrix background interference, which results in problematic analyses of biomolecules of less than 700 Da. Therefore, this study investigates hydrophilic, hydrophobic cationic, anionic and immobilized metal ion surface chemical modifications to advance nanostructured silicon mass spectrometry performance (nSi-MS). This investigation provides information required for a possible novel mass spectroscopy that combines surface-enhanced and nanostructured silicon surface-assisted laser desorption/ionization mass spectrometry for the selective detection of specific compounds of a mixture.

Graphical abstract: Nanostructured silicon surface modifications for as a selective matrix-free laser desorption/ionization mass spectrometry

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Article information

DOI
https://doi.org/10.1039/C2AN35189G
Article type
Paper
Submitted
09 Feb 2012
Accepted
26 Mar 2012
First published
27 Mar 2012

Analyst, 2012,137, 2643-2650

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Nanostructured silicon surface modifications for as a selective matrix-free laser desorption/ionization mass spectrometry

C. W. Tsao, C. H. Lin, Y. C. Cheng, C. C. Chien, C. C. Chang and W. Y. Chen, Analyst, 2012, 137, 2643 DOI: 10.1039/C2AN35189G

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