Jump to main content
Jump to site search

Issue 7, 2012
Previous Article Next Article

Rapid and on-site analysis of illegal drugs on the nano–microscale using a deep ultraviolet-visible reflected optical fiber sensor

Author affiliations

Abstract

A deep ultraviolet-visible (DUV-Vis) reflected optical fiber sensor was developed for use in a simple spectrophotometric detection system to detect the absorption of various illegal drugs at wavelengths between 180 and 800 nm. Quantitative analyses performed using the sensor revealed a high specificity and sensitivity for drug detection at a wavelength of approximately 200 nm. Using a double-absorption optical path length, extremely small sample volumes were used (32 to 160 nL), which allowed the use of minimal amounts of samples. A portable spectrophotometric system was established based on our optical fiber sensor for the on-site determination and quantitative analysis of common illegal drugs, such as 3,4-methylenedioxymethamphetamine (MDMA), ketamine hydrochloride, cocaine hydrochloride, diazepam, phenobarbital, and barbital. By analyzing the absorbance spectra, six different drugs were quantified at concentrations that ranged from 0.1 to 1000 μg mL−1 (16 pg–0.16 μg). A novel Matching Algorithm of Spectra Space (MASS) was used to accurately distinguish between each drug in a mixture. As an important supplement to traditional methods, such as mass spectrometry or chromatography, our optical fiber sensor offers rapid and low-cost on-site detection using trace amounts of sample. This rapid and accurate analytical method has wide-ranging applications in forensic science, law enforcement, and medicine.

Graphical abstract: Rapid and on-site analysis of illegal drugs on the nano–microscale using a deep ultraviolet-visible reflected optical fiber sensor

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Oct 2011, accepted on 11 Jan 2012 and first published on 03 Feb 2012


Article type: Paper
DOI: 10.1039/C2AN15953H
Citation: Analyst, 2012,137, 1596-1603

  •   Request permissions

    Rapid and on-site analysis of illegal drugs on the nano–microscale using a deep ultraviolet-visible reflected optical fiber sensor

    Q. Li, T. Qiu, H. Hao, H. Zhou, T. Wang, Y. Zhang, X. Li, G. Huang and J. Cheng, Analyst, 2012, 137, 1596
    DOI: 10.1039/C2AN15953H

Search articles by author

Spotlight

Advertisements