Issue 22, 2011
From the journal:

Analyst

A novel microreactor approach for analysis of ketones and aldehydes in breath

Xiao-An Fu,*a   Mingxiao Li,a   Souvik Biswas,b   Michael H. Nantzb  and  Richard M. Higashibcd  

* Corresponding authors

a Department of Chemical Engineering, University of Louisville, Louisville, KY, USA
E-mail: xiaoan.fu@louiville.edu

b Department of Chemistry, University of Louisville, Louisville, KY, USA

c Center for Regulatory and Environmental Analytical Metabolomics (CREAM), University of Louisville, Louisville, KY, USA

d James Graham Brown Cancer Center, University of Louisville, Louisville, KY

Abstract

We report a fabricated microreactor with thousands of micropillars in channels. Each micropillar surface is chemically functionalized to selectively preconcentrate gaseous ketones and aldehydes of exhaled breath and to enhance ultra-trace, rapid analysis by direct-infusion Fourier transform-ion cyclotron resonance (FT-ICR) mass spectrometry (MS). The micropillar reactive coating contains the quaternary ammonium aminooxy salt 2-(aminooxy)ethyl-N,N,N-trimethylammonium iodide (ATM) for capturing trace carbonyl VOCs by means of an oximation reaction. We demonstrate the utility of this approach for detection of C1 to C12aldehydes and ketones in exhaled breath, but the approach is applicable to any gaseous sample.

Graphical abstract: A novel microreactor approach for analysis of ketones and aldehydes in breath

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Article information

DOI
https://doi.org/10.1039/C1AN15618G
Article type
Communication
Submitted
19 Jul 2011
Accepted
19 Aug 2011
First published
06 Sep 2011

Analyst, 2011,136, 4662-4666

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A novel microreactor approach for analysis of ketones and aldehydes in breath

X. Fu, M. Li, S. Biswas, M. H. Nantz and R. M. Higashi, Analyst, 2011, 136, 4662 DOI: 10.1039/C1AN15618G

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